Innovation Showcase Pi-pi interaction-stabilized polymeric micelles as a novel platform for targeted drug delivery University Clinic
Tuesday, July 9, 2024
6:00 PM - 7:30 PM CET
Location: Sala Europa
Sponsored By
Josbert M Metselaar PharmD, PhD is a research pharmacist with an entrepreneurial background. He is passionate about nanoformulations in innovative health products, with a primary focus on medicines and an additional strong interest in health supplements and skincare. He has specific expertise in the preclinical and clinical development of advanced lipid- and polymer-based formulations.
Currently he works part-time with the team of the Department of Experimental Molecular Imaging at the RTWH University Clinic Aachen, Germany to foster the clinical translation of nanomedicines in the treatment of cancer.
The technology he is presenting in the CRS 2024 Innovation Showcase concerns a novel polymeric micellar drug delivery platform for hydrophobic API that are otherwise challenging to formulate. The technology features pi-pi core stabilization, which means that no chemical crosslinking is needed to encapsulate and stably retain drugs in vivo.
Manufacturing is robust and straightforward. The resulting drug-loaded pi-pi-stabilized polymeric micelles are small (around 50 nm or less) and show selective drug delivery to pathologic target sites, such as tumors and inflammatory lesions upon i.v. injection.
The technology is ready for industrial translation and can be produced under GMP. As an extra feature, it allows for co-encapsulation of radioactive tracers that enable tracking of the micelles in vivo, which will help identify patients most amenable to nanomedicine therapy.
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