Session: Tech Forum Determination of Critical Quality Attributes for ADC, NanoDDS and Gene Delivery tools from Research to Production
Tech Forum: Determination of Critical Quality Attributes for ADC, NanoDDS and Gene Delivery tools from Research to Production
Tuesday, July 9, 2024
8:00 AM – 9:00 AM CET
Location: Emilia
Sponsored By
Revolutionary advances in the landscape of pharmaceutical drug and gene delivery technologies are giving hope to patients suffering from previously incurable diseases. Researchers and manufacturers of these systems must ensure not only the efficacy but also the safety of these tools. At the biophysical level, critical quality attributes (CQAs) are the key parameters for evaluating and assessing the identity, purity, and stability of antibody-drug conjugates (ADCs), nanoDDS (nano drug delivery systems) and gene delivery tools. Given the increasing number and versatility of different delivery strategies, scientists face several challenges when it comes to the determination of CQAs.
Waters|Wyatt Technology is the leading provider of light scattering instrumentation for the quantification of quality attributes and other properties of gene therapy nanoparticles and protein-based drug delivery systems. Dynamic light scattering (DLS), electrophoretic light scattering (ELS) and multi-angle light scattering (MALS) enable screening and quality control to be performed in a timely and reliable manner. This technology talk will highlight the benefits of light scattering at various stages from early research to the manufacturing of the final pharmaceutical product including rapid detection of aggregates, executing formulation and stability studies, or performing in-depth characterization of identity, titer, purity, capsid content, or encapsulation efficiency.
