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Workshop: Long Acting Injectables Microsphere and Implant Design, Development and Scale Up Using ChronijectTM with ViatelTM Lactide / Glycolide Polymers

Monday, July 8, 2024
1:00 PM – 5:00 PM CET
Location: Magenta B

Sponsored By 
This event will focus on development and scale-up of long-acting injectable microspheres and implants.  Attendees will have an opportunity to learn about the selection of bioresorbable polymers and optimization of long-acting formulations with releases ranging from weeks to one year. Ashland, Oakwood Labs, MeltPrep and Sever will present together, respectively discussing how Ashland’s viatelTM bioresorbable polymers are optimized in various parenteral formulations. Oakwood Labs’ will discuss their ChronijectTM microsphere technology platform that offers reproducible, scalable, and consistent critical quality attributes under cGMP for multiple therapeutic indications.  Following talks will focus on implants, where MeltPrep will discuss a straightforward formulation screening tool with their vacuum compression molding (VCM) technology, while Sever Pharma will focus on their extrusion technologies, capable of forming bioresorbable implants at commercial scale.


Agenda


1:00 pm to 1:10 pm                            Welcome & General Introductions to the Session
                                                             Tom Durig, Ashland, USA

1:10 pm to 2:00 pm                            Cover LAI Overview and Key Excipients, Formulation Formats, Programming                                                                           Release through Custom Polymer Chemistry
                                                             Brad Minrovic, Ashland, USA
                                                             Patrick Duffy, Ashland, Ireland

2:00 pm to 2:10 pm                             Break

2:10 pm to 3:00 pm                             PLGA/PDLLA Microsphere Formulation Design and Scale-Up Demonstrated                                                                             Through Case Studies
                                                              Rachel Galaska, Oakwood Labs, USA

3:00 pm to 3:10 pm                             Break

3:10 pm to 3:45 pm                             Discussing Vacuum Compression Molding Technology for Designing                                                                                        Implants and Rapid Screening at R&D Scale
                                                              Andreas Bramböck, MeltPrep, Austria

3:45 pm to 4:20 pm                              Demonstrate Commercial Scale Extrusion of PLGA Implants through Case                                                                               Studies
                                                              Tony Listro, Sever Pharma, USA

4:20 pm to 4:25 pm                              Break

4:25 pm to 5:00 pm                              Transdermal Strategies for Long-Acting Delivery with PLGA  
                                                              Prof. Ryan Donnelly, Queens’ University Belfast, UK