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Session: Technical Session III

Nanomedicine and Nanoscale Delivery III

Wednesday, July 10, 2024
9:00 AM – 11:00 AM CET
Location: Sala Europa
Magnetic biohybrid microrobots for macrophage transport, activation, and imaging
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Adoptive cell transfers (ACTs) are rapidly growing in popularity due to the ability of cells to interact with diseased cells more specifically than small molecule drugs or injected particles. However, ACTs often lack methods to control the localization and function of cells within the body after injection. We have developed a class of non-spherical magnetic microrobots that bind to macrophages to remotely guide sustained cellular phenotypes and transport in physiological environments. For applications involving intravenous delivery, magnetic nanodisc “backpacks” stick to the surface of macrophages and are transported to inflamed sites by chemotaxis. For applications involving delivery through viscous barriers, helical particles facilitate cellular transport by swimming in rotating magnetic fields. These magnetic microrobots enhance control over ACT transport and enable tracking through magnetic particle imaging.