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Final Program


CRS Abstract Guide

YSC Scientific Workshop

Friday, July 12, 2024
8:00 AM - 10:00 AM CET
Location: Magenta A

Sponsored By 
Title: Inherently therapeutic fucoidan-based nanoparticles: from combination immunotherapy and advanced cell delivery to translational nanomedicine

Description: Our team utilized fucoidan, a natural polysaccharide, to engineer anti-tumor fucoidan-based nanoparticles (FuNPs). By tailoring their physicochemical properties, FuNPs exhibit distinct effects on nano-bio interactions, achieving P-selectin targeting, inhibiting tumor growth, activating the immune system, blocking the crosstalk between tumor cells and tumor-associated macrophages (TAMs), and modulating the tumor immune microenvironment (TIME). FuNPs can also be incorporated into mesenchymal stem cells (MSCs) to create a living drug delivery system. FuNPs developed in our lab demonstrate strong translational potential for clinical cancer applications. Our lead candidate, INSP003, a polysaccharidic docetaxel, is expected to finalize the IND package for phase I/IIa studies in 2025.