Delivery of nucleic acids such as mRNA, pDNA, oligonucleotides (siRNA, ASOs) using delivery platforms such as lipid nanoparticles, polymeric nanoparticles, liposomes, inorganic nanoparticles, virus-like particles, conjugates, exosomes and biomimetic particles for expression of therapeutic proteins, modulation of protein expression, genome editing for disease modification, and vaccination. Advances in particle characterization, biological limitations of systems (endosomal escape, cellular targeting, tissue targeting / biodistribution) to advance the field of nucleic acid delivery fall within scope of this focus group.
| Poster # | First Name | Last Name | Abstract Title | Abstract |
| 172 |
Elisa | Lázaro-Ibáñez | Engineered Extracellular Vesicles for Targeted Ligand Display and Therapeutic Protein Delivery | View |
| 246 | Giulia | Anderluzzi | Understanding the impact of cationic polymer on the cytotoxicity and DNA transfection efficiency of lipopolyplexes | View |
| 247 | Joachim | Arikibe | Supramolecular Oligocationic Polymeric Bioconjugates for Systemic Nucleic Acid Delivery | View |
| 248 | Nithiyaa | Bala Krishnan | Lipid-functionalized Ionizable Polypeptides for mRNA Delivery | View |
| 249 | Raquel | Bártolo | Functional study of atrial natriuretic peptide conjugated spermine-acetalated dextran nanoparticles loaded with miRNA for heart tissue regeneration after myocardial infarction | View |
| 251 | Jessie | Boulos | Development of a Targeted Stimuli-Responsive Peptide System to Deliver Bioactive siRNA for Glioblastoma Multiforme Treatment | View |
| 252 |
Oscar | Boyadjian | Extracellular vesicles subpopulations yield different DNA encapsulation efficiencies | View |
| 253 | Annalisa | Bozza | “Green” Solid Lipid Nanoparticles by the fatty acids coacervation: a sustainable nanocarrier for gene-delivery | View |
| 254 | Roberta | Cavalli | CN3 Research at UniTO in the framework of Precision Medicine: a focus on Multifunctional Synthetic Nanoplatforms for Targeted Delivery | View |
| 256 | Ilaria | Chiarugi | Optimization of Nanoparticles for Enhanced siRNA Delivery: Comparative Investigation of Cationic Lipids | View |
| 257 | Ju Yeon | Chung | A nanoplatform for the delivery of antisense oligonucleotides (ASOs) to treat multi-drug resistant fungal infections | View |
| 258 | Martina | Coletto | Hybrid nanoparticles for targeted microRNA delivery to cardiomyocytes | View |
| 259 | Gabriella | Costabile | Exploiting the potential of hybrid lipid polymer nanoparticles for delivery of RNA therapeutics to the lung | View |
| 260 | Mittal | Darji | Development of novel ionizable lipid nanoparticles for enhanced siRNA delivery | View |
| 261 | Bryan | Debiasi | Devevelopment of liquid crystalline nanoparticles for RNA delivery via intranasal route | View |
| 262 | Andrea | del Valle | Dopamine-Coated Calcium Phosphate Nanoparticles for pH Controlled Release of siRNA | View |
| 263 | Jan | Egger | Bioinspired guanidinium-containing poly(methacrylamide) polymers for gene delivery with modified hydrophilic-lipophilic balance | View |
| 265 | Francesca | Ferraresso | Global protein expression after intravenous infusion of mRNA-lipid nanoparticles in swine | View |
| 266 | Teresa | Ferrillo | On the role of PEG-lipids in the development of Lipid Nanoparticles for siRNA delivery | View |
| 267 | Thomas | Foster | Ursodeoxycholic Acid in Polymer Nanoparticles for Gene Therapy in Ocular Cells | View |
| 268 | Kristina | Friis | Formulation optimization results in successful spray drying of lipid nanoparticles with functional mRNA delivery to the lungs. | View |
| 270 | Antonella | Grigoletto | Lipid-based systems for the delivery of plasmid DNA | View |
| 272 | Cherry | Gupta | Delivery of large plasmids to neuronal cells using cationic polymeric nanoparticles. | View |
| 273 | Christopher | Hauß | Cationic amphiphilic drugs as a new tool in RNA formulation development | View |
| 274 |
Stijn | Hofstraat | Apolipoprotein-based nanoparticle platform for gene silencing in bone marrow stem and progenitor cells | View |
| 275 | Jinmyoung | Joo | Enhanced intracellular transfection of CRISPR/Cas9 using fusogenic nanoparticles | View |
| 276 |
Sabah | Kasmi | A reducible carbamate ionizable lipid library tailored towards intramuscular and systemic therapeutic applications | View |
| 277 | Eunbin | Kim | Optimization of mRNA structure for the enhancement of stability and translational activity | View |
| 278 | Vandana | Krishna | Development of Survivin mRNA loaded lipid nanoparticles for oral cancer Immunotherapy | View |
| 281 | Philipp | Lapuhs | Diffusive nanocarrier-mediated mRNA delivery to the brain | View |
| 282 | Chiara | Lazzarini | Design and Optimization of the Transfection Efficiency of PEI/pDNA polyplexes using Design of Experiments (DoE) | View |
| 284 | Kyuri | Lee | Development of mRNA structures and delivery systems for modulating immunogenicity | View |
| 285 | Yeji | Lee | Enhancing neutralization potency of mRNA-ionizable lipid nanoparticle vaccine based on analysis of immune system | View |
| 288 | Aida | Lopez Espinar | Optimising the design of ionizable amino-polyester lipid nanoparticles for tissue selective mRNA delivery | View |
| 289 | Zhanjun | Ma | An optimized lipid nanoparticle formulation for the delivery of microRNA-124 skews microglia toward a pro-resolutive phenotype | View |
| 290 | Cheng | MA | Pulmonary delivery of mRNA using peptide-based vector by nebulization | View |
| 291 | Nipuni | Maniyamgama | Muco-Penetrating Lipid Nanoparticles Having a Liquid Core for Enhanced Intranasal mRNA Delivery | View |
| 292 | Lara | Marcenta | Engineered lipoplexes for miRNA restoration in leukemic T-Large Granular Lymphocytes | View |
| 293 | Raquel | Martinez-Campelo | Delivery of immunostimulatory viral proteins from gene-activated matrices for glioblastoma treatment. | View |
| 295 | Franziska | Mitrach | siRNA Delivery via Cross-Linked Gelatine Microparticles for Bone Tissue Engineering | View |
| 296 | Jeffrey | Momoh | Multimodal and multiscale imaging of lipid nanoparticle-mediated RNA delivery | View |
| 298 | Niren | Murthy | Acid degradable lipid nanoparticles efficiently deliver mRNA in vivo | View |
| 300 | Daniela | Orefice | In vitro testing of microneedles for transdermal vaccines. | View |
| 301 | Preeti | SHARMA | Structure-Activity Relationship (SAR) between Ionizable Lipid Structure and Immune Cell Responses | View |
| 302 | Zhengyu | Piao | Hyaluronic acid-Gold Nanoparticle/CRISPR Complexes for Targeted Gene Editing | View |
| 303 | Yuan | Ping | An oncolytic virus–T-cell chimera for cancer immunotherapy | View |
| 304 | Giovanni | Protopapa | Non-viral gene delivery at best through VibroFect technology | View |
| 305 | Giovanni | Protopapa | Elevating non-viral transfection of cells through VibroFect technology | View |
| 306 | Venkatesh | Ravula | Next-Generation surfactants with Tethered Cationic Headgroups as Gene Delivery Vectors | View |
| 307 | Madelaine | Robertson | Optimization and Delivery of Endogenous mRNA UTRs using Lipid Nanoparticles to Control Exogenous Protein Expression in Platelets | View |
| 309 | Elisa | Schiavon | Avidin Nucleic Acid NanoASsemblies (ANANAS) for targeted gene delivery: development of a multifunctional platform. | View |
| 310 | Hanäé | Guérin | Oral administration of mRNA-based nanomedicines for the treatment of inflammatory bowel diseases | View |
| 311 | Luis | Sotelo Marmolejo | Synthesis of P-NIPAAmco-P-(1-vinylimidazole) and P-NIPAAm-co-P-(4-vinylpyridine) temperature and pH sensitive nanogels as novel gene delivery carriers. | View |
| 312 | Martina | Stocco | Platforms for RNA therapeutics delivery: Fusogenic ANANAS-based system for targeted delivery of siRNA/miRNA | View |
| 313 | Michael | Streiber | Organic solvent-free lipid nanoparticle enabling multiple gene delivery, CRISPR-Cas9 application and expression in primary monocytes | View |
| 314 | Gozde | Tezcan | Hermes™ lipopolyplex nanoparticles confer enhanced stability over mRNA LNPs | View |
| 315 | Sophie | Thalmayr | Modulating mRNA transfection efficiency and cytotoxicity of lipoamino fatty acid xenopeptides by spacer and disulfide linkage effects | View |
| 316 | Vincent | Venditto | Triazine lipids as novel gene delivery vehicles with enhanced mRNA transgene expression | View |
| 317 | Xiaoqin | Wang | Hybrid extracellular vesicles for efficient loading and functional delivery of mRNA | View |
| 318 | Xiaoxuan | Wang | NMR-dynamic monitoring of sheddable coatings from the lipid nanoparticle surface | View |
| 319 | Lucian | Williams | Polymeric Micelle Delivery of Cas9 Ribonucleoprotein for HEK293-GFP Gene Knockdown | View |
| 320 | Yi Yan | Yang | Ionizable lipids made by facile synthesis for effective delivery of mRNA vaccine | View |
| 321 | Emily | Young | Hermes™ lipopolyplex nanoparticles for linear hpDNA™ delivery | View |
| 323 | Yongshun | Zhang | Adeno-associated virus-mediated reactivation of tumor suppressor PTEN enhances antitumor immunity | View |
| 495 |
Darran | Andrews | Rapid, Accurate Quantitation of RNA in Lipid Nanoparticles (LNPs) – An End to Fluorescence Assays? | View |
| 501 | Mariah | Arral | The Effects of Age and Sex on Lipid Nanoparticle Mediated mRNA Delivery | View |
| 690 | Wathsala | Liyanage | Targeted cellular delivery of CRISPR-Cas 9 ribonucleoproteins using dendrimer nanoparticles. | View |
| 1253 |
Ersilia | Villano | Transitioning hybrid lipid polymer NPs from lab to bulk scale production with microfluidic | View |
